張旭
研究員，研究組組長，博士生導(dǎo)師
Email：xu.zhang@@www.plm-bat.com
個人簡介：
張旭，神經(jīng)科學(xué)家，中國科學(xué)院院士，發(fā)展中國家科學(xué)院院士，中國醫(yī)學(xué)科學(xué)院學(xué)術(shù)咨詢委員會學(xué)部委員。1994年7月在瑞典卡羅琳斯卡醫(yī)學(xué)院神經(jīng)科學(xué)系獲博士學(xué)位。1994年先后在第四軍醫(yī)大學(xué)神經(jīng)科學(xué)研究所任講師、副教授和研究員、神經(jīng)科學(xué)研究所副所長。1999年12月任中國科學(xué)院上海生命科學(xué)研究院神經(jīng)科學(xué)研究所研究員、感覺系統(tǒng)研究組組長。2021年2月任中國科學(xué)院上海高等研究院研究員，2021年3月任上海腦-智工程中心主任，2021年6月任廣東省智能科學(xué)與技術(shù)研究院院長?，F(xiàn)任廣東省智能科學(xué)與技術(shù)研究院院長、研究員和研究組組長，兼任中國神經(jīng)科學(xué)學(xué)會理事長、中國細(xì)胞生物學(xué)學(xué)會副監(jiān)事長、中華醫(yī)學(xué)會疼痛分會副主任委員等職。
軀體感覺神經(jīng)網(wǎng)絡(luò)研究組：
本研究組主要從事軀體感覺的神經(jīng)網(wǎng)絡(luò)研究。軀體感覺包括了痛、癢、溫度等感覺，背根節(jié)的初級感覺神經(jīng)元是軀體感覺傳入的第一站，其外周支投射到皮膚、肌肉等組織，感受外界的痛、癢、溫度等信息，其中樞支投射到脊髓，再經(jīng)大腦的不同區(qū)域傳向大腦皮層，從而實(shí)現(xiàn)軀體感覺的感受。我們以往的研究發(fā)現(xiàn)了成纖維細(xì)胞生長因子13（FGF13）和內(nèi)源性鈉鉀泵激動劑濾泡素抑制素樣蛋白1（FSTL1）等新的痛覺信息調(diào)控系統(tǒng)，為臨床鎮(zhèn)痛及藥物研發(fā)提供了新的理論基礎(chǔ)。近年來，我們發(fā)展了背根節(jié)初級感覺神經(jīng)元的單細(xì)胞測序技術(shù)，對初級感覺神經(jīng)元進(jìn)行了新的分類，確定了一些標(biāo)記性分子，建立了細(xì)胞類群與在體功能的相互關(guān)系。目前我們致力于發(fā)現(xiàn)各類群初級感覺神經(jīng)元對痛、癢等軀體感覺調(diào)制具有重要意義的感覺神經(jīng)傳遞網(wǎng)絡(luò)，研究中樞神經(jīng)系統(tǒng)中痛、癢等軀體感覺神經(jīng)網(wǎng)絡(luò)的交互作用。
外周神經(jīng)損傷和持續(xù)炎癥可以引起病理性痛，早期我們在實(shí)驗(yàn)室發(fā)展了來自大鼠背根節(jié)的 cDNA 微陣列技術(shù)，系統(tǒng)性地闡述了慢性痛的背根節(jié)和脊髓基因表達(dá)譜，發(fā)現(xiàn)在外周神經(jīng)損傷后背根節(jié)和脊髓背角中離子通道、受體和信號轉(zhuǎn)導(dǎo)分子的基因表達(dá)發(fā)生了顯著的變化，為外周神經(jīng)損傷后引起背根節(jié)和脊髓背角獨(dú)特的基因表達(dá)譜提供了證據(jù)。2021年我們利用單細(xì)胞測序技術(shù)進(jìn)一步揭示了神經(jīng)損傷導(dǎo)致的神經(jīng)病理性痛引起的初級感覺神經(jīng)元細(xì)胞類群的變化以及相應(yīng)的功能改變。目前我們致力于發(fā)現(xiàn)神經(jīng)病理性痛發(fā)生時的神經(jīng)環(huán)路結(jié)構(gòu)改變，并揭示其與神經(jīng)病理性痛發(fā)生的相關(guān)性，解析其對認(rèn)知等大腦功能的影響及環(huán)路機(jī)制。
本課題組招收2024年度北京師范大學(xué)、南方醫(yī)科大學(xué)、西北工業(yè)大學(xué)、北京協(xié)和醫(yī)學(xué)院、澳門大學(xué)聯(lián)合培養(yǎng)博士研究生，申請考核制，具有生物學(xué)、醫(yī)學(xué)專業(yè)碩士學(xué)位或應(yīng)屆碩士畢業(yè)生，有神經(jīng)科學(xué)研究背景優(yōu)先，有意者發(fā)送簡歷至yujindi@www.plm-bat.com。
代表論著：
1. Cai B., Wu D., Xie H., Chen Y., Wang H-D., Jin S., Song Y-R., Li A-A., Huang S-Q., Wang S-S., Lu Y-J., Bao L., Xu F-Q., Gong H., Li C-L., and Zhang X. (2023) A direct spino-cortical circuit bypassing the thalamus modulates nociception. Cell Res., 33: 775-789.
2. Wang K-K., Cai B., Song Y-R., Chen Y., and Zhang, X. (2023). Somatosensory neuron types and their neural networks as revealed via single-cell transcriptomics. Trends in Neuroscience, 46: 654-666.
3. Chen Y., Song Y-R., Wang H-Z., Zhang Y-Y., Hu Y., Wang K-K., Lu Y-J., Zhang Z, Li S., Li A-A., Bao L., Xu F-Q., Li C-L., and Zhang X. (2022) Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors. PNAS, 119: e2118501119.
4. Zhang S., Cai B., Li Z., Wang K-K., Bao L., Li C-L., and Zhang X. (2022) Fibroblastic SMOC2 suppresses mechanical nociception by inhibiting coupled activation of primary sensory neurons. J Neurosci, 42: 4069-4086.
5. Wu D., Chen Y., Li Z., Xie H., Wang S-S., Lu Y-J., Bao L., Zhang X., and Li C-L. (2022) Zcchc12-containing nociceptors are required for noxious heat sensation. J Neurosci, 42: 2690-2700.
6. Pan X-Y., Zhao J-R., Zhou Z-Y., Chen J-J., Yang Z-X., Wu Y-X., Bai M-Z., Jiao Y, Yang Y, Hu X-Y., Cheng T-L., Lu Q-Y., Wang B, Li C-L, Lu Y-J, Diao L, Zhong Y-Q, Pan J, Zhu J-M., Xiao H-S, Qiu Z-L, Li J, Wang Z-F., Hui J-Y., Bao L, and Zhang X. (2021) 5’-UTR SNP of FGF13 causes translational defect and intellectual disability. eLife, 10: e63021.
7. Wang K-K., Wang S-S., Chen Y., Wu D., Hu X-Y., Lu Y-J., Wang L-P., Bao L., Li C-L., and Zhang X. (2021) Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain. Cell Res., 31: 904-918.
8. Dong F., Shi H-X., Yang L., Xue H-Q., Wei M-Y., Zhong Y-Q., Bao L., and Zhang X. (2020) FGF13 is required for histamine-induced itch sensation by interaction with Nav1.7. J. Neurosci. 40: 9589-9601.
9. Li J-Y., Shi H-X., Liu H., Dong F., Liu Z-P., Lu Y-J., Chen L-N., Bao L., and Zhang X. (2020) Nerve injury-induced neuronal PAP-I maintains neuropathic pain by activating spinal microglia. J. Neurosci., 40: 297–310.
10. Yang L., Dong F., Yang Q., Yang P-F., Wu R., Wu Q-F., Wu D., Li C-L., Zhong Y-Q., Lu Y-J., Cheng X., Xu F-Q., Chen L., Bao L., and Zhang X. (2017) FGF13 selectively regulates heat nociception by interacting with Nav1.7. Neuron, 93: 806-821.
11. Li C-L., Li K-C., Wu D., Chen Y., Luo H., Zhao J-R., Wang S-S., Sun M-M., Lu Y-J., Zhong Y-Q., Hu X-Y., Hou R., Zhou B-B., Bao L., Xiao H-S., and Zhang X. (2016) Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity. Cell Res., 26: 83-102.
12. Liu H., Wu Q-F., Li J-Y., Liu X-J., Li K-C., Zhong Y-Q., Wu D., Wang Q., Lu Y-J., Bao L., and Zhang X. (2015) Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles. J. Mol. Cell Biol., 7: 466-475.
13. Wang F., Cai B., Li K-C., Hu X., Lu Y., Wang Q., Bao L., and Zhang X. (2015) FXYD2, a γ subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation. Cell Res., 25: 318-334.
14. Zhang X., Bao L., Li S. (2015) Opioid receptor trafficking and interaction in nociceptors. Br. J. Pharmacol., 172: 364–374. (Review)
15. Wu Q-F., Yang L., Li S., Wang Q., Yuan X-B., Gao X., Bao L., and Zhang X. (2012) Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell, 149: 1549-1564.
16. Liu X-J., Zhang F-X., Liu H., Li K-C., Lu Y-J., Wu Q-F., Li J-Y., Wang B., Wang Q., Lin L-B., Zhong Y-Q., Xiao H-S., Bao L., and Zhang X.（2012）Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain. Brain, 135: 391-403.
17. Li K-C., Wang F., Zhong Y-Q., Lu Y-J., Wang Q., Zhang F-X., Xiao H-S., Bao L., and Zhang X. (2011) Reduction of follistatin-like 1 in primary afferent neurons contributes to neuropathic pain hypersensitivity. Cell Res., 21: 697-699.
18. Li K-C., Zhang F-X., Li C-L., Wang F., Yu M-Y., Zhong Y-Q., Zhang K-H., Lu Y-J., Wang Q., Ma X-L., Yao J-R., Wang J-Y., Lin L-B., Han M., Zhang Y-Q., Kuner R., Xiao H-S., Bao L., Gao X., and Zhang X. (2011) Follistatin-like 1 suppresses sensory afferent transmission by activating Na+,K+-ATPase. Neuron, 69: 974-987.
19. Zhao B., Wang H-B., Lu Y-J., Hu J-W., Bao L., and Zhang X. (2011) Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesicles. Cell Res., 21: 741-753.
20. He S-Q., Zhang Z-N., Guan J-S., Liu H-R., Zhao B, Wang H-B., Li Q., Yang H., Luo J., Li Z-Y., Wang Q., Lu Y-J., Bao L., and Zhang X. (2011) Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron, 69: 120-131.
21. Zhang F-X., Liu X-J., Gong L-Q., Yao J-R., Li K-C., Li Z-Y., Lin L-B., Lu Y-J., Xiao H-S., Bao L., Zhang X-H., and Zhang X. (2010) Inhibition of inflammatory pain by activating B-Type natriuretic peptide signal pathway in nociceptive sensory neurons. J. Neurosci., 30: 10927-10938.
22. Wang H-B., Zhao B., Zhong Y-Q., Li K-C., Li Z-Y., Wang Q., Lu Y-J., Zhang Z-N., He S-Q., Zheng H-C., Wu S-X., H?kfelt T-G., Bao L., and Zhang X. (2010) Coexpression of δ- and μ-opioid receptors in nociceptive sensory neurons. Proc. Natl. Acad. Sci. USA, 107: 13117-13122.
23. Zhang X., Bao L., and Ma G-Q. (2010) Sorting of neuropeptides and neuropeptide receptors into secretory pathway. Prog. in Neurobiol., 90: 276-283. (Review)
24. Zhang X., Bao L., and Guan J-S. (2006) Role of delivery and trafficking of δ-opioid peptide receptors in opioid analgesia and tolerance. Trends in Pharmacol. Sci., 27: 324-329. (Review)
25. Zhang X. and Bao L. (2006) The development and modulation of nociceptive circuitry. Curr. Opin. Neurobiol., 16: 460-466 (Review)
26. Guan J-S., Xu Z-Z., Gao H., He S-Q., Ma G-Q., Sun T., Wang L-H., Zhang Z-N., Lena I., Kitchen I., Elde R., Zimmer A., He C., Pei G., Bao L. and Zhang X. (2005) Interaction with vesicle luminal protachykinin regulates surface expression of δ-opioid receptors and opioid analgesia. Cell, 122: 619-631.
27. Zhang X. and Xiao H-S. (2005) Gene array analysis to determine the components of neuropathic pain signaling. Curr. Opin. Mol. Ther., 7: 532-537. (Review)
28. Yang L., Zhang F-X., Huang F., Lu Y-J., Li G-D., Bao L., Xiao H-S., and Zhang X. (2004) Peripheral axotomy induces trans-synaptic modification of channels, receptors and signaling pathways in rat dorsal spinal cord. Eur. J. Neurosci., 19: 871-883.
29. Bao L., Jin S-X., Zhang C., Wang L-H., Xu Z-Z., Zhang F-X., Wang L-C., Ning F-S., Cai H-J., Guan J-S., Xiao H-S., Xu Z-Q., He C., H?kfelt T., Zhou Z., and Zhang X. (2003) Activation of delta-opioid receptors induces receptor insertion and neuropeptide secretion. Neuron, 37: 121–133.
30. Xiao H-S., Huang Q-H., Zhang F-X., Bao L., Lu Y-J., Guo C., Yang L., Huang W-J., Fu G., Xu S-H., Cheng X-P., Yan Q., Zhu Z-D., Zhang X., Chen Z., Han Z-G., and Zhang X. (2002) Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc. Natl. Acad. Sci. USA., 99: 8360-8365.
31. Bao L., Wang H-F., Cai H-J., Tong Y-G., Jin S-X., Lu Y-J., Grant G., H?kfelt T., and Zhang X. (2002) Peripheral axotomy induces only very limited sprouting of coarse myelinated afferents into inner lamina II of rat spinal cord. Eur. J. Neurosci., 16: 175-185.
32. Tong Y-G., Wang H-F., Ju G., Grant G., H?kfelt T., and Zhang X. (1999) Increased uptake and transport of cholera toxin B-subunit in dorsal root ganglion neurons after peripheral axotomy: possible implications on sensory sprouting. J. Comp. Neurol., 404: 143-158.
