鮑嵐
博士，特聘研究員
Email:baolan@@www.plm-bat.com
個(gè)人簡(jiǎn)介
鮑嵐研究員，廣東省智能科學(xué)與技術(shù)研究院特聘研究員，原中國(guó)科學(xué)院分子細(xì)胞科學(xué)卓越創(chuàng)新中心課題組長(zhǎng)、博士生導(dǎo)師，2003年獲國(guó)家自然科學(xué)杰出青年基金資助，2008年獲中科院“百人計(jì)劃”資助。主要從事神經(jīng)系統(tǒng)調(diào)控的分子細(xì)胞機(jī)制研究，已在國(guó)際學(xué)術(shù)期刊發(fā)表80余篇學(xué)術(shù)論文。曾承擔(dān)國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目和國(guó)家重大研究計(jì)劃項(xiàng)目，獲得軍隊(duì)科技進(jìn)步一等獎(jiǎng)和二等獎(jiǎng)各1次、上海市科學(xué)技術(shù)進(jìn)步二等獎(jiǎng)1次。享受?chē)?guó)務(wù)院政府特殊津貼，獲上海市“三八”紅旗手榮譽(yù)稱(chēng)號(hào)、中國(guó)科學(xué)院朱月李華優(yōu)秀教師獎(jiǎng)、上海市志愿服務(wù)先進(jìn)集體、中國(guó)細(xì)胞生物學(xué)學(xué)會(huì)科普工作先進(jìn)分子?，F(xiàn)兼任中國(guó)神經(jīng)科學(xué)學(xué)會(huì)常務(wù)理事、中國(guó)細(xì)胞生物學(xué)學(xué)會(huì)常務(wù)理事、上海市創(chuàng)新細(xì)胞生物學(xué)發(fā)展基金會(huì)副理事長(zhǎng)、中國(guó)細(xì)胞生物學(xué)學(xué)會(huì)女科學(xué)家工作委員會(huì)副主任。
代表論著：(*corresponding author)
1.Chen Y, Chen Q, Song Y, Wang H, Hu X, Wang K, Wu X, Xu F, Bao L and Zhang X. (2024) Tracing from periphery to cortex: application of herpes simplex virus to somatosensory neural networks. Neurosci. Bull, 40: 1739–1744.
2.Diao L, Liu M, Liu Y, Zhang X and Bao L*. (2023) Microtubules composed of α4A undergo curved growth mainly mediated by its core structure. J Mol Cell Biol, 15: mjad004.
3.Wang B, Jiang B, Li GW, Dong F, Luo Z, Cai B, Wei M, Huang J, Wang K, Feng X, Tong F, Wang S, Wang Q, Han Q, Li C, Zhang X, Yang L and Bao L*. (2022) Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice. EMBO Reports, 24: e54313.
4.Huang J, Jiang B, Li GW, Zheng D, Li M, Xie X, Pan Y, Wei M, Liu X, Jiang X, Zhang X, Yang L, Bao L* and Wang B*. (2022) m6A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation. Cell Rep, 41: 111693.
5.Zhang S, Cai B, Li Z, Wang KK, Bao L, Li CL and Zhang X. (2022) Fibroblastic SMOC2 suppresses mechanical nociception by inhibiting coupled activation of primary sensory neurons. J Neurosci, 42: 4069-4086.
6.Diao L, Liu MY, Song YL, Zhang X, Liang X* and Bao L*. (2021) α1A and α1C form microtubules to display distinct properties mainly mediated by their C-terminal tails. J Mol Cell Biol, 13: 864-875.
7.Xie X, Wang SG, Li MY, Diao L, Pan XY, Chen JJ, Zhang X, Feng WF* and Bao L*. (2021) α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation. Nat Commun, 12: 4113.
8.Pan X, Zhao J, Zhou Z, Chen J, Yang Z, Wu Y, Bai M, Jiao Y, Yang Y, Hu X, Cheng T, Lu Q, Wang B, Li CL, Lu YJ, Diao L, Zhong YQ, Pan J, Zhu J, Xiao HS, Qiu ZL, Li J, Wang Z, Hui J, Bao L*, Zhang X*. (2021) 5’-UTR SNP of FGF13 causes translational defect and intellectual disability. eLife, 10: e63021.
9.Wang K, Wang S, Chen Y, Wu D, Hu X, Lu YJ, Wang L, Bao L, Li CL and Zhang X. (2021) Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain. Cell Res, 31: 904-918.
10.Wei MY, Huang JS, Li GW, Jiang BW, Cheng H, Liu XY, Jiang XY, Zhang X, Yang L, Bao L* and Wang B*. (2021) Axon-enriched lincRNA ALAE is required for axon elongation via regulating local mRNA translation. Cell Rep, 35: 109053.
11.Feng WF, Liu R, Xie X, Diao L, Gao NN, Cheng JK, Zhang X, Li Y and Bao L*. (2021) SUMOylation of α-tubulin is a novel modification regulating microtubule dynamics. J Mol Cell Biol, 13: 91–103.
12.Dong F, Shi HX, Yang L, Xue HQ, Wei MY, Zhong YQ, Bao L* and Zhang X*. (2020) FGF13 is required for histamine-induced itch sensation by interaction with NaV1.7. J Neurosci, 40: 9589-9601.
13.Li JY, Shi HX, Liu H, Dong F, Liu ZP, Lu YJ, Chen LN, Bao L* and Xu Zhang*. (2020) Nerve injury-induced neuronal PAP-I maintains neuropathic pain by activating spinal microglia. J Neurosci, 40: 297-310.
14.Wei D, Gao NN, Li L, Zhu JX, Diao L, Huang JS, Han QJ, Wang SG, Xue HQ, Wang Q, Wu QF, Zhang X and Bao L*. (2018) α-Tubulin acetylation restricts axon overbranching by dampening microtubule plus-end dynamics in neurons. Cerebral Cortex, 28: 3332-3346.
15.Yang L, Dong F, Yang Q, Yang PF, Wu R, Wu QF, Wu D, Li CL, Zhong YQ, Lu YJ, Cheng X, Xu FQ, Chen L, Bao L and Zhang X. (2017) FGF13 selectively regulates heat nociception by interacting with Nav1.7. Neuron, 93: 806-821.
16.Wang B and Bao L*. (2017) Axonal microRNAs: localization, function and regulatory mechanism during axon development. J. Mol. Cell Biol., 9: 82-90.
17.Li CL, Li KC, Wu D, Chen Y, Luo H, Zhao JR, Wang SS, Sun MM, Lu YJ, Zhong YQ, Hu XY, Hou R, Zhou BB, Bao L, Xiao HS and Zhang X. (2016) Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity. Cell Res., 26: 83-102.
18.Wang B, Pan L, Wei M, Wang Q, Liu WW, Wang N, Jiang XY, Zhang X and Bao L*. (2015) FMRP-mediated axonal delivery of miR-181d regulates axon elongation by locally targeting Map1b and Calm1. Cell Rep, 13: 2794-2807.
19.Bao L*. (2015) Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons. Mol. Pain, 11: 61
20.Chen XQ, Zhu JX, Wang Y, Zhang X and Bao L*. (2014) CaMKIIα and caveolin-1 cooperate to drive ATP-induced membrane delivery of the P2X3 receptor. J. Mol. Cell Biol., 6: 140-153.
21.Su YY, Ye M, Li L, Liu C, Pan J, Liu WW, Jiang Y, Jiang XY, Zhang X, Shu Y and Bao L*. (2013) KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8. J. Neurosci., 33: 17884-17896.
22.Han QJ, Gao NN, Ma GQ, Zhang ZN, Yu WH, Pan J, Wang Q, Zhang X and Bao L*. (2013) IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF-β/Smad signaling. J. Cell Sci., 126: 542-553.
23.Li L, Wei D, Wang Q, Pan J, Liu R, Zhang X and Bao L*. (2012) MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons. J. Neurosci., 32: 12673-12683.
24.Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X and Bao L*. (2012) Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res., 22: 677-696.
25.Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L and Zhang X. (2012) Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell, 149:1549-1564.
26.Zhao B, Wang HB, Lu YJ, Hu JW, Bao L and Zhang X. (2011) Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesicles. Cell Res., 21: 741-753.
27.He SQ, Zhang ZN, Guan JS, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ, Bao L* and Zhang X*. (2011) Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron, 69: 120-131.
28.Li Q, Su YY, Wang H, Li L, Wang Q and Bao L*. (2010) Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation. J. Biol. Chem., 285: 32977-32987.
29.Wang HB, Zhao B, Zhong YQ, Li KC, Li ZY, Wang Q, Lu YJ, Zhang ZN, He SQ, Zheng HC, Wu SX, H?kfelt TGM, Bao L*, and Zhang X*. (2010) Coexpression of δ- and μ-opioid receptors in nociceptive sensory neurons. Proc Natl Acad Sci U S A., 107: 13117-13122.
30.Liu C, Li Q, Su YY and Bao L* (2010) Prostaglandin E2 promotes Nav1.8 trafficking via its intracellular RRR motif through the protein kinase A pathway. Traffic, 11: 405-417.
31.Ma GQ, Wang B, Wang HB, Wang Q and Bao L* (2008) Short elements with charged amino acids form clusters to sort protachykinin into large dense-core vesicles. Traffic, 9: 2165–2179.
32.Zhang ZN, Li Q, Liu C, Wang HB, Wang Q and Bao L* (2008) Voltage-gated sodium channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit. J. Cell Sci. 121: 3243-3252.
