蔡冰

博士,副研究員

Email:bcai@@www.plm-bat.com

個人簡介:

2011年本科畢業(yè)于山東大學(xué),2018年博士畢業(yè)于中國科學(xué)院神經(jīng)科學(xué)研究所(現(xiàn)中國科學(xué)院腦科學(xué)與智能技術(shù)卓越創(chuàng)新中心),2018-2020年掛靠中國科學(xué)院上海藥物研究所在上海腦中心進(jìn)行博士后研究,自2021年8月加入廣東省智能科學(xué)與技術(shù)研究院軀體感覺神經(jīng)網(wǎng)絡(luò)研究組先后擔(dān)任助理研究員和副研究員。

研究方向:

主要研究軀體感覺信息處理的神經(jīng)環(huán)路,綜合運(yùn)用神經(jīng)束路示蹤、電生理、行為學(xué)、單細(xì)胞測序等技術(shù),探索新的脊髓上行傳導(dǎo)通路及其對感覺信息的處理,解析脊髓上行傳導(dǎo)通路在外周神經(jīng)損傷引起的慢性痛過程中的變化及功能。

代表論著:

1. Cai B*., Wu D*., Xie H*., Chen Y., Wang H-D., Jin S., Song Y-R., Li A-A., Huang S-Q., Wang S-S., Lu Y-J., Bao L., Xu F-Q., Gong H., Li C-L., and Zhang X. (2023) A direct spino-cortical circuit bypassing the thalamus modulates nociception. Cell Res., 33: 775-789.

2. Wang K-K., Cai B., Song Y-R., Chen Y., and Zhang, X. (2023). Somatosensory neuron types and their neural networks as revealed via single-cell transcriptomics. Trends in Neuroscience., 46: 654-666.

3. Zhang S., Cai B., Li Z., Wang K-K., Bao L., Li C-L., and Zhang X. (2022) Fibroblastic SMOC2 suppresses mechanical nociception by inhibiting coupled activation of primary sensory neurons. The Journal of Neuroscience., 42(4069-4086).

4. Wang B., Jiang B-W., Li G-W., Dong F., Luo Z., Cai B., Wei M-Y., Huang J-S., Wang K-K., Feng X., Tong F., Wang S-S., Wang Q., Han Q-J., Li C-L., Zhang X., Yang L., and Bao L. (2022) Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice. EMBO reports., 24(e54313).

5. Luo H., Cai B., Pan J., Shi H-X., Wang K-K., Zhong Y-Q., Lu Y-J., Bao L., Zhang X., and Li K-C. (2021) FXYD6 promotes thermal nociception by regulating TRPV1. Molecular Pain., 17(1): 1-15.

6. Li K-C., Cai B., Li C-L., and Zhang X. (2017) Presynaptic inhibition of nociceptive neurotransmission by somatosensory neuron-secreted suppressors. SCIENCE CHINA Life Sciences., 60: 1013-1018.

7. Wang F*., Cai B*., Li K-C*., Hu X-Y., Lu Y-J., Wang Q., Bao L., and Zhang X. (2015) FXYD2, a γ subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation. Cell Res., 25: 318-334


張旭研究組