劉學釗
博士，研究員，研究組組長
Email: liuxuezhao@@www.plm-bat.com
個人簡介：
劉學釗，研究員，腦認知與髓鞘發(fā)育研究組組長。2006年本科畢業(yè)于天津科技大學，2009年碩士畢業(yè)于南開大學，2015年于中國科學院大學取得博士學位。于2017年7月至2025年1月在美國辛辛那提兒童醫(yī)院醫(yī)學中心從事博士后研究工作。參與完成了美國國家多發(fā)性硬化癥協(xié)會 (National Multiple Sclerosis Society) 的科研項目。 代表性研究成果以第一及共同第一作者身份發(fā)表在《Cell》、《Nature Neuroscience》和《Journal of Cell Biology》等國際頂尖期刊上。
腦認知與髓鞘發(fā)育研究組
在中樞神經(jīng)系統(tǒng)中，髓鞘（myelin）是由少突膠質(zhì)細胞（oligodendrocytes，OLs）生成的一種重要結(jié)構(gòu)。髓鞘在維持神經(jīng)系統(tǒng)正常功能中扮演著不可或缺的角色，它能夠顯著提升神經(jīng)信號的傳導(dǎo)速度并優(yōu)化能量利用效率。髓鞘的缺陷或損傷與多種神經(jīng)系統(tǒng)疾病密切相關(guān)，例如神經(jīng)系統(tǒng)發(fā)育障礙、智力障礙以及阿爾茲海默癥等。此外，髓鞘還為神經(jīng)元軸突的長期功能和存活提供了關(guān)鍵的神經(jīng)營養(yǎng)因子、生長因子及能量物質(zhì)支持。基于這些發(fā)現(xiàn)，我們的研究目標是在全腦規(guī)模神經(jīng)網(wǎng)絡(luò)領(lǐng)域?qū)崿F(xiàn)突破，深入揭示神經(jīng)網(wǎng)絡(luò)信號高速高效傳遞的內(nèi)在機制，從而為相關(guān)疾病的治療和神經(jīng)科學的進一步發(fā)展奠定理論基礎(chǔ)。
代表論著：
1. Liu X*, Xin E*, Zhong X*, Zhao C*, Li Z, Zhang L, Dourson A, Lee L, Mishra S, Bayat A, Nicholson E, Seibel W, Yan B , Mason J, Turner B , Gonsalvez D, Ong W, Chew S, Ghosh B, Yoon S , Xin M, He Z, Tchieu J, Wegner M, Nave K, Franklin R, Dutta R, Trapp B, Hu M, Smith M, Jankowski M, Barton S, He X, and Lu Q.(2024) Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration. Cell. Apr 25: S0092-8674(24)00400-8. doi: 10.1016/j.cell.2024.04.005
2. Huang G*, Li Z*, Liu X* (Co-first author), Guan M, Zhou S, Zhong X, Zheng T, Xin D, Guo X, Mu D, Guo Y, Zhang L, Zhang L, Lu Q, and He X. (2024) DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice. Nat Neurosci. 2024 Sep 12. doi: 10.1038/s41593-024-01754-9.
3. Liu X*, Li Y*, Wang X, Xing R, Liu K, Gan Q, Tang C, Gao Z, Jian Y, Luo S, Guo W, Yang C. (2017). The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. J Cell Biol. 2017 Apr 12. pii: jcb.201608039. doi: 10.1083/jcb.201608039
4. Wang J, Yang L, Du Y, Wang J, Weng Q, Liu X, Nicholson E, Xin M and Lu Q. (2024) BRG1 programs PRC2-complex repression and controls oligodendrocyte differentiation and remyelination. J Cell Biol. 2024;223(7): e202310143. doi:10.1083/jcb.202310143
5. Hu X*, Wu X*, Berry K, Zhao C, Xin D, Ogurek S, Liu X, Zhang L, Luo Z, Sakabe M, Trubicka J, ?astowska M, Szulzewsky F, Holland EC, Lee L, Hu M, Xin M, Lu QR. (2023) Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis. Nat Cell Biol. 2023 Feb;25(2):323-336. doi:10.1038/s41556-022-01069-6.
6. Luo Z*, Xia M*, Shi W*, Zhao C*, Wang J*, Xin D, Dong X, Xiong Y, Zhang F, Berry K, Ogurek S, Liu X, Rao R, Xing R, Wu LMN, Cui S, Xu L, Lin Y, Ma W, Tian S, Xie Q, Zhang L, Xin M, Wang X, Yue F, Zheng H, Liu Y, Stevenson CB, de Blank P, Perentesis JP, Gilbertson RJ, Li H, Ma J, Zhou W, Taylor MD, Lu QR. (2022) Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis. Nature. 2022 Dec;612(7941):787-794. doi: 10.1038/s41586-022-05487-2.
7. Wang J, Yang L, Jiang M, Zhao C, Liu X, Berry K, Waisman A, Langseth AJ, Novitch BG, Bergles DE, Nishiyama A, Lu QR. (2022) Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination. J Neurosci. 2022 Nov 9;42(45):8542-8555. doi: 10.1523/JNEUROSCI.0237-22.2022.
8. Wu LMN, Zhang F, Rao R, Adam M, Pollard K, Szabo S, Liu X, Belcher KA, Luo Z, Ogurek S, Reilly C, Zhou X, Zhang L, Rubin J, Chang LS, Xin M, Yu J, Suva M, Pratilas CA, Potter S, Lu QR. (2022) Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy. Sci Adv. 2022 Nov 4;8(44): eabo5442. doi: 10.1126/sciadv. abo5442.
9. Wang M *, Tang C *, Xing R, Liu X, Han X, Liu Y, Wang L, Yang C, and Guo W. (2021). WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFbeta signaling. Molecular psychiatry 26, 694-709. doi: 10.1038/s41380-018-0307-y.
10. Zhang L *, He X *, Liu X, Zhang F, Huang L.F, Potter A.S, Xu L, Zhou W, Zheng T, Luo Z, Berry KP, Pribnow A, Smith SM, Fuller C, Jones BV, Fouladi M, Drissi R, Yang ZJ, Gustafson WC, Remke M, Pomeroy SL, Girard EJ, Olson JM, Morrissy AS, Vladoiu MC, Zhang J, Tian W, Xin M, Taylor MD, Potter SS, Roussel MF, Weiss WA, Lu QR. (2019). Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer cell 36, 302-318 e307. doi: 10.1016/j.ccell.2019.07.009
11. He X*, Zhang L*, Queme LF, Liu X, Lu A, Waclaw RR, Dong X, Zhou W, Kidd G, Yoon SO, Buonanno A, Rubin JB, Xin M, Nave KA, Trapp BD, Jankowski MP, Lu QR.(2018) A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nat Med. 2018 Mar;24(3):338-351. doi: 10.1038/nm.4483.
12. Li Y, Zhang Y, Gan Q, Xu M, Ding X, Tang G, Liang J, Liu K, Liu X, Wang X, Guo L, Gao Z, Hao X, & Yang C. (2018). C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death. Protein & cell 9, 1013-1026. doi: 10.1007/s13238-018-0520-0.
13. Liu K*, Jian Y*, Sun X*, Yang C, Gao Z, Zhang Z, Liu X, Li Y, Xu J, Jing Y, Mitani S, He S, Yang C. (2016) Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. J. Cell Biol.212(2):181-98. doi: 10.1083/jcb.201506081.
14. Li Y*, Xu M*, Ding X, Song Z, Huang X, Jian Y, Tang G, Yan C, Di Y, Liu X, Liu K, Li T, Wang Y, Guo W, Hao X, Yang C.(2016). Protein kinase C is a master switch of lysosome biogenesis independent of mTORC1. Nat Cell Biol. 2016 Oct;18(10):1065-77. doi: 10.1038/ncb3407.
15. Chen D *, Jian Y *, Liu X, Zhang Y, Liang J, Qi X, Du H, Zou W, Chen L, Chai Y, Ou G, Miao L, Wang Y & Yang C. (2013). Clathrin and AP2 Are Required for Phagocytic Receptor-Mediated Apoptotic Cell Clearance in Caenorhabditis elegans. PLOS Genetics, 9(5): e1003517. doi: 10.1371/journal.pgen.1003517.
