Dan Larhammar
研究員，研究組組長，博士生導(dǎo)師，瑞典皇家科學(xué)院院士，歐洲科學(xué)院院士
Email: danlarhammar@@www.plm-bat.com
個(gè)人簡介：
Dan Larhammar，研究員，認(rèn)知與衰老研究組組長。瑞典皇家科學(xué)院院士、歐洲科學(xué)院院士、國際科學(xué)理事會會士、烏普薩拉大學(xué)分子細(xì)胞生物學(xué)教授、瑞典皇家科學(xué)院院長（2018-2022）。他于1984年獲得瑞典烏普薩拉大學(xué)醫(yī)學(xué)科學(xué)博士學(xué)位，早期研究集中在對食欲調(diào)節(jié)有重要作用的神經(jīng)肽Y（NPY）的功能。作為訪問學(xué)者在加利福尼亞斯克里普斯研究所工作一年后，他專注于NPY受體的克隆和分子藥理學(xué)研究，發(fā)現(xiàn)了多個(gè)NPY受體，闡明了其在脊椎動(dòng)物中的進(jìn)化過程及藥理學(xué)特性。隨后他的研究擴(kuò)展到了脊椎動(dòng)物眼睛的分子進(jìn)化，特別是視網(wǎng)膜中桿狀細(xì)胞和錐狀細(xì)胞的起源，以及神經(jīng)遞質(zhì)和激素及其受體的進(jìn)化，還研究了與帕金森病相關(guān)的多巴胺受體。近年來，他致力于研究學(xué)習(xí)和長期記憶的分子機(jī)制，重點(diǎn)關(guān)注谷氨酸受體（AMPA和NMDA家族）及其相關(guān)的調(diào)節(jié)蛋白。
認(rèn)知與衰老研究組
本研究組圍繞學(xué)習(xí)和記憶的機(jī)制主要開展兩方面的研究：一方面聚焦于研究谷氨酸受體在學(xué)習(xí)和記憶的過程中的功能以及其與各種調(diào)節(jié)蛋白質(zhì)相互作用的復(fù)雜機(jī)制；另一方面開展對于糖胺聚糖如乙酰硫酸肝素和硫酸軟骨素在學(xué)習(xí)和腦衰老過程中的研究。這些研究工作通過利用轉(zhuǎn)基因斑馬魚、小鼠以及細(xì)胞模型來開展。
相關(guān)的研究方法包括利用單細(xì)胞RNA測序分析識別與長期記憶相關(guān)的細(xì)胞群體和基因，利用空間轉(zhuǎn)錄組學(xué)分析確定學(xué)習(xí)和記憶相關(guān)腦區(qū)表達(dá)的關(guān)鍵分子，利用野生型和轉(zhuǎn)基因型斑馬魚進(jìn)行學(xué)習(xí)和記憶的行為研究，還使用小鼠和斑馬魚模型研究阿爾茨海默病的發(fā)生機(jī)制。
近期代表性論著
（全部論著見網(wǎng)站：https://www.uu.se/en/contact-and-organisation/staff?query=N96-4750）
196. Criveanu, D., Bergqvist, C. A., Larhammar, D., and Walczewska-Szewc, K. Identification of a new Kir6 potassium channel and comparison of properties of Kir6 subtypes by structural modelling and molecular dynamics. Int. J. Biol. Macromol. 9;247:125771 (2023). PMID: 37433419.
195. Lagman, D., Haines, H. J., Abalo, X. M., and Larhammar, D. Ancient multiplicity in cyclic nucleotide-gated (CNG) cation channel repertoire was reduced in the ancestor of Olfactores before re-expansion by whole genome duplications in vertebrates. PLOS ONE, e0279548 (2022). PMID: 36584110.
194. Morini, M., Bergqvist, C. A., Asturiano, J. F., Larhammar, D., and Dufour, S. Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses. Front. Endocrinol. 13:1013868 (2022). PMID: 36387917.
193. Li, Y., Pan, Y., Wang, Y., Jiang, Z., Akakuru, O. U., Li, M., Zhang, X., Yuan, B., Xing, J., Luo, L., Larhammar, D., Wu, A., Li, J. A D-peptide ligand of neuropeptide Y receptor Y1 serves as nanocarrier traversing of the blood brain barrier and targets glioma. Nano Today 44, 101465 (2022).
192. Ocampo Daza, D., Bergqvist, C. A., and Larhammar, D. The evolution of oxytocin and vasotocin receptor genes in jawed vertebrates: a clear case for gene duplications through ancestral whole-genome duplications. Frontiers Endocrinol. 264, 94-112 (2022). PMID: 35185783.
191. Garcia Concejo, A. and Larhammar, D. Protein kinase C family evolution in jawed vertebrates. Dev. Biol. 479, 77-90 (2021). PMID: 34329618.
188. Abalo, X. M., Lagman, D., Heras, G., Del Pozo, A., Eggert, J., and Larhammar, D. Circadian regulation of phosphodiesterase 6 genes in zebrafish differs between cones and rods: Implications for photopic and scotopic vision. Vision Res. 166, 43-51 (2020). PMID: 31855667.
186. Shebanits, K., Vasile, S., Xu, B., Gutiérrez-de-Terán, H., and Larhammar, D. Functional characterization in vitro of twelve naturally occurring variants of the human pancreatic polypeptide receptor NPY4R. Neuropeptides 76:101933 (2019). PMID: 31230758.
184. Pedersen, J. E., Bergqvist, C. A., and Larhammar, D. Evolution of vertebrate nicotinic acetylcholine receptors. BMC Evol. Biol. 19:38 (2019). PMID: 30700248.
183. Pedersen, J. E., Bergqvist, C. A., and Larhammar, D. Evolution of the muscarinic acetylcholine receptors in vertebrates. eNeuro 5, 1-12 (2018). PMID: 30564629.
181. Shebanits, K., Andersson-Assarsson, J. C., Larsson, I., Carlsson, L. M. S., Feuk, L., and Larhammar, D. Copy number of pancreatic polypeptide receptor gene NPY4R correlates with body mass index and waist circumference. PLOS ONE 13(4):e0194668 (2018). PMID: 29621259.
180. Yang, Z., Han, S., Keller, M., Burkert, K., Bender, B. J., Bosse, M., Kaiser, A., K?gler, L. M., Wifling, D., Bernhardt, G., Plank, N., Littmann, T., Schmidt, P., Yi, C., Li, B., Ye, S., Zhang, R., Xu, B., Larhammar, D., Stevens, R. C., Huster, D., Meiler, J., Zhao, Q., Beck-Sickinger, A. G., Buschauer, A., and Wu, B. Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor. Nature 556, 520-524 (2018). PMID: 29670288.
178. Ocampo Daza D. and Larhammar D. Evolution of the growth hormone (GH), prolactin (PRL) and somatolactin (SL) family. Gen. Comp. Endocrinol. 264, 94-112 (2018). PMID: 29339183.
177. Ocampo Daza, D. and Larhammar, D. Evolution of the receptors for growth hormone, prolactin, erythropoietin and thrombopoietin in relation to the vertebrate tetraploidizations. Gen. Comp. Endocrinol. 257, 143-160 (2018). PMID: 28652136.
176. Lagman, D., Franzén, I. E., Eggert, J., Larhammar, D., and Abalo, X. M. Evolution and expression of phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. BMC Evol. Biol., 16:124 (2016). PMID: 27296292.
174. Xu, B., Lagman, D., Sundstr?m, G., and Larhammar, D. Neuropeptide Y family receptors Y1 and Y2 from sea lamprey, Petromyzon marinus. Gen. Comp. Endocrinol. 222, 106-115 (2015). PMID: 26255155.
Review article #15. Elphick, M. R., Mirabeau, O., and Larhammar, D. Evolution of neuropeptide signalling systems. J. Exp. Biol. 9, 221 (2018). PMID: 29440283. Correction in PMID: 30305362.
