丘志海
博士，研究員，研究組組長(zhǎng)
主要研究方向：
多尺度神經(jīng)網(wǎng)絡(luò)成像和操控
致力于開(kāi)發(fā)光和聲無(wú)創(chuàng)腦成像和神經(jīng)調(diào)控技術(shù)，并將其應(yīng)用于腦功能研究和腦疾病治療。
Email: qiuzhihai@@www.plm-bat.com
個(gè)人簡(jiǎn)介：
2019年畢業(yè)于香港理工大學(xué)生物醫(yī)學(xué)工程專業(yè)，獲生物醫(yī)學(xué)工程博士學(xué)位。2019-2022年在美國(guó)斯坦福大學(xué)醫(yī)學(xué)院從事博士后研究。獲得多項(xiàng)國(guó)際會(huì)議（包括神經(jīng)科學(xué)、生物物理、生物醫(yī)學(xué)工程、光學(xué)工程等領(lǐng)域權(quán)威國(guó)際會(huì)議）獎(jiǎng)項(xiàng)。相關(guān)研究成果在PNAS、Cell Reports、iScience、Advanced Science、 Brain stimulation, Advanced Photonics Research、IEEE TUFFC、STAR Protocols等學(xué)術(shù)期刊上發(fā)表。主持國(guó)自然面上項(xiàng)目1項(xiàng)。申請(qǐng)中國(guó)發(fā)明專利6項(xiàng)，美國(guó)專利4項(xiàng)。受邀在牛津大學(xué)《經(jīng)顱腦調(diào)控工具書(shū)》撰寫(xiě)超聲神經(jīng)調(diào)控章節(jié)。是STAR Protocols雜志的Advisory board member。
多尺度神經(jīng)網(wǎng)絡(luò)成像和操控研究組：
目前主要聚焦超聲神經(jīng)調(diào)控和超聲腦功能成像技術(shù)及其應(yīng)用研究。
超聲波是一種較安全的能量形式，在腦功能成像和神經(jīng)調(diào)控中顯示出越來(lái)越明朗的應(yīng)用前景。平面波超聲可以快速對(duì)全腦的血流灌注進(jìn)行成像，得到類似于血氧水平依賴性功能磁共振（BOLD-fMRI）信息。超聲系統(tǒng)相對(duì)簡(jiǎn)單和小巧，相比于功能核磁可以用較低的成本實(shí)現(xiàn)自由移動(dòng)生物體的全腦功能成像。我們開(kāi)發(fā)了全胚胎功能成像策略，有望成為臨床產(chǎn)檢新方法，為胚胎發(fā)育研究提供新技術(shù)新方法。另一方面，研究顯示低能量低頻率聚焦超聲作為一種機(jī)械波，可以打開(kāi)機(jī)械敏感通道蛋白，在神經(jīng)刺激、神經(jīng)-免疫調(diào)控等方面都有很大的應(yīng)用前景。我們從中發(fā)展起來(lái)了基于MscL-G22s（一種細(xì)菌中發(fā)現(xiàn)的機(jī)械敏感通道蛋白）的超聲遺傳學(xué)技術(shù)，已經(jīng)被法國(guó)學(xué)者獨(dú)立驗(yàn)證，日益受到關(guān)注。在這些研究基礎(chǔ)上，我們正致力于開(kāi)發(fā)全聲學(xué)的跨尺度神經(jīng)網(wǎng)絡(luò)成像和操控技術(shù)（包括基于超聲遺傳學(xué)的全腦神經(jīng)網(wǎng)絡(luò)解構(gòu)方法、全腦-脊成像和刺激技術(shù)），并探索它們?cè)谂R床前和臨床轉(zhuǎn)化中的應(yīng)用。
此外，為了拓展光和聲在顱骨和腦組織中的穿透深度，我們正在開(kāi)發(fā)光和聲的波前調(diào)控技術(shù)，希望推動(dòng)光和聲相關(guān)技術(shù)在基礎(chǔ)研究和臨床轉(zhuǎn)化中的應(yīng)用。
本課題組長(zhǎng)期招聘聯(lián)合培養(yǎng)博士生，F(xiàn)PGA工程師，感興趣的同學(xué)，請(qǐng)郵件聯(lián)系。
代表論著：
[1] Jiejun Zhu, Dongming He, Mengzhu Sun, Hanming Zheng, Zihao Chen, Jing Yang, Chengqi Lin, Yun Stone Shi, Lei Sun,* Zhihai Qiu*. Functional imaging of whole mouse embryonic development in utero. bioRxiv, 2024
[2] Xuandi Hou, Jianing Jing, Yizhou Jiang, Xiaohui Huang, Quanxiang Xian, Ting Lei, Jiejun Zhu, Kin Fung Wong, Xinyi Zhao, Min Su, Danni Li, Langzhou Liu, Zhihai Qiu, Lei Sun*. Nanobubble-actuated ultrasound neuromodulation for selectively shaping behavior in mice. Nature Communications, 2024, 15(1): 2253
[3] Quanxiang Xian#, Zhihai Qiu#, Shashwati Kala, Derek King Fung Wong, Yong Wu, Xuandi Hou, Jinghui Guo, Lei Sun*. Modulation of deep neural circuits with sonogenetics. PNAS, 2023, 120(23): e2220575120
[4] Jiejun Zhu, Quanxiang Xian, Xuandi Hou, Kin Fung Wong, Tingting Zhu, Zihao Chen, Dongming He, Shashwati Kala, Suresh Murugappan, Jianing Jing, Yong Wu, Xinyi Zhao, Danni Li, Jinghui Guo, Zhihai Qiu*, Lei Sun*. The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation. PNAS, 2023, 120(18): e2300291120
[5] Tianyi Liu, Mi Hyun Choi, Jiejun Zhu, Tingting Zhu, Jin Yang, Na Li, Zihao Chen, Quanxiang Xian, Xuandi Hou, Dongmin He, Jinghui Guo, Chunlong Fei, Lei Sun, Zhihai Qiu*. Sonogenetics: Recent advances and future directions. Brain stimulation, 2022, 15(5): 1308-1317
[6] Na Li, Zihao Chen, Jiejun Zhu, Mi Hyun Choi, Jin Yang, Zhen Yuan, Lei Sun, Chunlong Fei, Zhihai Qiu*. Measuring sound velocity based on acoustic resonance using multiple narrow band transducers. Heliyon, 2023, 9(3): 230145
[7] Zhihai Qiu, Mihyun Choi, Ningrui Li, Kim Butts Pauly, Direct neural activation by ultrasound. (In preparation)
[8] Zhihai Qiu, Shashwati Kala, Jinghui Guo, Quanxiang xian, Jiejun Zhu, Ting Zhu, Xuandi Hou, King Fung Wong, Minyi Yang, Haoru Wang, Lei Sun*. Targeted neurostimulation in mouse brains with non-invasive ultrasound. Cell Reports, 2020, 32(7), 108033
[9] Zhihai Qiu, Jinghui Guo, Shashwati Kala, Jiejun Zhu, Quanxiang Xian, Weibao Qiu, Guofeng Li, Ting Zhu, Long Meng, Rui Zhang, Hsiao Chang Chan, Hairong Zheng*, Lei Sun*. The mechanosensitive ion channel Piezo1 significantly mediates in vitro ultrasonic stimulation of neurons. iScience, 2019, 21: 448-457
[10] Xuandi Hou#,Zhihai Qiu#, Jinghui Guo, Ting Zhu, Lei Sun*, Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators. Advanced Science, 2021, 2101934
[11] Keith R Murphy, Jordan S Farrell, Juan L Gomez, Quintin G Stedman, Ningrui Li, Steven A Leung, Cameron H Good, Zhihai Qiu, Kamyar Firouzi, Kim Butts Pauly, Butrus Pierre T Khuri-Yakub, Michael Michaelides, Ivan Soltesz, Luis de Lecea. A tool for monitoring cell type–specific focused ultrasound neuromodulation and control of chronic epilepsy. PNAS, 2022, 119(46): e2206828119
[12] Tianting Zhong#, Zhihai Qiu#, Jinhui Guo, Huanhao Li, Zhipeng Yu, Shengfu Cheng, Yingying Zhou, Jiejun Zhu, Jie Tian*, Lei Sun*, and Puxiang Lai*, Spatiotemporally engineered neuron stimulation (STENS) through mouse skull with a wavefront shaping-empowered multimode fiber. Advanced photonic research, accepted
[13] Quanxiang Xian#, Zhihai Qiu#, Shashwati Kala, Jiejun Zhu, Jinghui Guo and Lei Sun*, Protocol for the sonogenetic stimulation of mouse brain by non-invasive ultrasound. STAR Protocols, 2021, 2 (2), 100393
[14] Quanxiang Xian#, Zhihai Qiu#, Shashwati Kala, Jinghui Guo, and Lei Sun*, Behavioral and functional assessment of ultrasound neuromodulation on Caenorhabditis elegans. IEEE TUFFC, 2021, 68(6), 2150 – 2154
[15] Jinghui Guo, Yong Wu, Zhiyong Gong, Xixi Chen, Fei Cao, shashwati Kala, Zhihai Qiu et al, Photonic nanojet-mediated optogenetics, Advanced Science, accepted.
[16] Zhaoxi Li, Dafeng Wang, Chunlong Fei*, Zhihai Qiu et al, The Forbidden Band and Size Selectivity of Acoustic Radiation Force Trapping, iScience, 2020, 2021, 24(1): 101988.
