王颯爽
博士，助理研究員
Email：wangsashuang@@www.plm-bat.com
個人簡介：
2014年于河南大學取得學士學位，2021年在中國科學院腦科學與智能技術(shù)卓越創(chuàng)新中心（中科院神經(jīng)所）獲神經(jīng)生物學博士學位。研究成果主要發(fā)表于Cell Research、Neurosci Bull和J Neurosci等雜志。曾主持國家自然科學基金青年基金項目，作為科研骨干參與國家自然科學基金重大項目課題。
主要研究方向：
博士研究生期間主要利用單細胞測序技術(shù)研究外周神經(jīng)損傷后基因表達變化及調(diào)控機制，篩選治療神經(jīng)病理性痛的藥物靶點。目前的工作方向為軀體感覺相關(guān)疾病，基于大數(shù)據(jù)分析探索神經(jīng)病理性痛、慢性癢等軀體感覺相關(guān)疾病的發(fā)生發(fā)展機制。利用10x Genomics單細胞測序、在體RNA干擾、RNAscope原位雜交、體外鈣成像等技術(shù)，發(fā)掘新的關(guān)鍵靶點。
代表論著
1. Wu S#, Wang S#, Lin X, Yang S, Ba X, Xiong D, Xiao L, Li R. Lanatoside C inhibits herpes simplex virus 1 replication by regulating NRF2 distribution within cells. Phytomedicine. 2024 Feb;124:155308. (#, co-first authors)
2. Cai B, Wu D, Xie H, Chen Y, Wang H, Jin S, Song Y, Li A, Huang S, Wang S, Lu Y, Bao L, Xu F, Gong H, Li C, Zhang X. A direct spino-cortical circuit bypassing the thalamus modulates nociception. Cell Res. 2023 Oct;33(10):775-789.
3. Luo QT, Ye YC, Guo WM, Zhu Q, Wang SS, Li N, Wang L, Cheng CS, Fan G. Senolytic Treatment Improve Small Intestine Regeneration in Aging. Aging Dis. 2023 Sep 26.
4. Wang B, Jiang B, Li GW, Dong F, Luo Z, Cai B, Wei M, Huang J, Wang K, Feng X, Tong F, Wang S, Wang Q, Han Q, Li C, Zhang X, Yang L, Bao L. Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice. EMBO Rep. 2023 Feb 6;24(2):e54313.
5. Yang S, Liu X, Wang M, Cao D, Jaijyan DK, Enescu N, Liu J, Wu S, Wang S, Sun W, Xiao L, Gu A, Li Y, Zhou H, Tyagi S, Wu J, Tang Q, Zhu H. Circular RNAs Represent a Novel Class of Human Cytomegalovirus Transcripts. Microbiol Spectr. 2022 Jun 29;10(3): e0110622.
6. Wu D, Li Z, Wang SS, Zhang S, Lu YJ, Bao L, Zhang X, Li CL. Zcchc12-Containing Nociceptors Are Required for Noxious Heat Sensation. J Neurosci. 2022 Mar 30;42(13):2690-2700.
7. Zhou J, Sun W, Liu Y, Yang S, Wu S, Wang S, Xiong D, Ho IH, Zhang L, Chan MTV, Wu WKK, Liu X, Xiao L. Clinical Characteristics, Treatment Effectiveness, and Predictors of Response to Pharmacotherapeutic Interventions Among Patients with Herpetic-Related Neuralgia: A Retrospective Analysis. Pain Ther. 2021 Dec;10(2):1511-1522.
8. Wang KK#, Wang SS#, Chen Y, Wu D, Hu XY, Lu YJ, Wang LP, Bao L, Li CL*, Zhang X*. Single-Cell Transcriptomic Analysis of Somatosensory Neurons Uncovers Temporal Development of Neuropathic Pain. Cell Res. 2021 Aug;31(8):904-918. (#, co-first authors; *, co-corresponding authors)
9. Li CL, Wang SS, Chen Y, Zhang X. Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis. Neurosci Bull. 2018 Feb;34(1):200-207.
10. Li CL#, Li KC#, Wu D, Chen Y, Luo H, Zhao JR, Wang SS, Sun MM, Lu YJ, Zhong YQ, Hu XY, Hou R, Zhou BB, Bao L, Xiao HS, Zhang X. Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity. Cell Res. 2016; 26:83-102.
