郭玉潔
博士，助理研究員
Email:guoyujie@@www.plm-bat.com
個人簡介：
中國科學(xué)技術(shù)大學(xué)合肥微尺度物質(zhì)科學(xué)國家研究中心神經(jīng)生物學(xué)博士，四川大學(xué)華西醫(yī)院生物治療國家重點實驗室基礎(chǔ)醫(yī)學(xué)博士后。2022年8月加入廣東省智能科學(xué)與技術(shù)研究院，主要關(guān)注神經(jīng)和精神疾病環(huán)路機制。既往研究包括：建立了一種新型的自殘動物模型，在此基礎(chǔ)上發(fā)現(xiàn)了多個與動物自殘相關(guān)的腦區(qū)，繪制了第一張自殘相關(guān)腦區(qū)圖譜，解開了一條情緒影響自殘行為的通路。以第一（含共同）作者身份發(fā)表學(xué)術(shù)論文多篇。主持國家自然科學(xué)基金青年科學(xué)基金、中國博士后科學(xué)基金面上資助（一等）、四川省科技廳重點研發(fā)項目等國家和省部級科研項目多項。
研究方向：
[1]自殘行為/抑郁癥的神經(jīng)環(huán)路機制
[2]α-突觸核蛋白腦內(nèi)傳播擴散的神經(jīng)環(huán)路機制
代表論著：
[1] Guo Y, Tang X, Zhang J, Jin S, Li J, Ding L, Zhang K, Yang C, Zhou H, He X, Xu F, Bi G-Q, Xu L & Lau P-M. Corticosterone signaling and a lateral habenula-ventral tegmental area circuit modulate compulsive self-injurious behavior in a rat model. Journal of Neuroscience, 2018, 38(23): 5251-5266. (reported by AAAS)
[2] Guo Y, Xiong H, Chen K, Zou J, Lei P, Brain regions susceptible to alpha-synuclein spreading. Molecular Psychiatry, 2022, 27(1): 758-770.
[3] Guo Y, Ayton S, Lei P. Iron reduces the propagation of pathological α-synuclein: An Editorial Highlight for "Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils" on page 554. Journal of Neurochemistry, 2021, 159(3): 414-416.
[4] Wang H, Zhu Q, Ding L, Shen Y, Yang C-Y, Xu F, Shu C, Guo Y, Xiong Z, Shan Q, Jia F, Su P, Yang Q-R, Li B, Cheng Y, He X, Chen X, Wu F, Zhou J-N, Xu F, Han H, Lau P-M, Bi G-Q, 2 / 3 Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution. National Science Review, 2019, 6(5): 982-992.
[5] Xiong H, Tuo Q, Guo Y, Lei P, Diagnostics and treatments of iron-related CNS diseases. Advances in Experimental Medicine and Biology, 2019, 1173: 179-194.
[6] Tuo Q, Liu Y, Xiang Z, Yan H, Zou T, Shu Y, Ding X, Zou J, Xu S, Tang F, Gong Y, Li X, Guo Y, Zheng Z, Deng A, Yang Z, Li W, Zhang S, Ayton S, Bush A, Xu H, Dai L, Dong B, Lei P, Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion. Signal Transduction and Targeted Therapy, 2022, 7: 1-15.
[7] Luoqian J, Yang W, Ding X, Tuo Q, Xiang Z, Zheng Z, Guo Y, Ayton S, Dong B, Zhang H, Hu H, Lei P, Guan P, Li L, Ferroptosis promotes T cell activation-induced neurodegeneration in multiple sclerosis. Cellular & Molecular Immunology, 2022. 19(8):913-924
